Inhibitory effects of deoxynivalenol on pathogenesis of Candida albicans.

摘要: AIMS To probe the inhibitory effects of deoxynivalenol (DON) on growth and biofilms yeast bacterial pathogens. METHODS AND RESULTS Crystal violet quantification, XTT reduction assay, confocal scanning electron microscopic imaging, yeast-to-hyphal inhibition assays were performed to demonstrate DON. Our results show that DON its modified form (3-acetyl-DON) caused dose-dependent Candida albicans pathogenesis under in vitro conditions. significantly reduced C. biofilm formation metabolic activities, disrupted preformed without affecting planktonic cell growth, inhibited hyphal protrusions in embedded colonies free-living cells. We also derivatives function by interacting with lanosterol 14α-demethylase, thus mimicking action mechanism azole drugs. CONCLUSIONS Highlighting importance filamentations inducing pathogen vigour, this study demonstrates antihyphal antibiofilm potential against albicans. SIGNIFICANCE IMPACT OF THE STUDY Mycotoxin-producing moulds are able dominate control other microbes insects ecological niches. At times, they known eradicate their intruders or symbiotic partners. In view coincident notion, proposes a role for mycotoxins as inhibitor