Poor Cell Survival Limits the Beneficial Impact of Mesenchymal Stem Cell Transplantation on Acute Kidney Injury

摘要: Background: Although renal tubular epithelium has a great capacity for repair it been suggested that the administration of mesenchymal stem cells may accelerate recovery following severe ischemic injury. Methods: Here we analyzed survival rate and organ distribution transplanted as well their contribution to kidney regeneration after injury using functional tests, histological examination quantitative real-time PCR. Results: Intravenously injected were mainly trapped in lungs liver. One hour injection, less than 1% could be detected injured kidneys. These disappeared within first few days did not replace epithelial precluding substantial transdifferentiation. To clarify whether reinforced cell delivery might promote sustained or conversion epithelia, directly into these grafted also show contribute structural repair, injection was associated with significant but transient initial decrease serum creatinine. Conclusion: data suggest do significantly renewal injury, promoting idea major impact cell-based therapy acute result from paracrine endocrine effects unrelated