Associations of Ambulatory Blood Pressure With Urinary Caffeine and Caffeine Metabolite Excretions

摘要: Intake of caffeinated beverages might be associated with reduced cardiovascular mortality possibly via the lowering blood pressure. We estimated association ambulatory pressure urinary caffeine and metabolites in a population-based sample. Families were randomly selected from general population Swiss cities. Ambulatory monitoring was conducted using validated devices. Urinary caffeine, paraxanthine, theophylline, theobromine excretions measured 24 hours urine ultrahigh performance liquid chromatography tandem mass spectrometry. used mixed models to explore associations although adjusting for major confounders. The 836 participants (48.9% men) included this analysis had mean age 47.8 24-hour systolic diastolic 120.1 78.0 mm Hg. For each doubling excretion, night-time decreased by 0.642 1.107 Hg (both P values <0.040). Similar inverse observed paraxanthine theophylline. Adjusted first (lowest), second, third, fourth (highest) quartile 110.3, 107.3, 105.1 Hg, respectively (P trend <0.05). No generally found, excretion not Anti-hypertensive therapy, diabetes mellitus, alcohol consumption modify inversely other metabolites. Our results are compatible potential protective effect on