Diagnostic examination performance by using microvascular leakage, cerebral blood volume, and blood flow derived from 3-T dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging in the differentiation of glioblastoma multiforme and brain metastasis

摘要: Conventional magnetic resonance (MR) imaging has limited capacity to differentiate between glioblastoma multiforme (GBM) and metastasis. The purposes of this study were: (1) compare microvascular leakage (MVL), cerebral blood volume (CBV), flow (CBF) in the distinction metastasis from GBM using dynamic susceptibility-weighted contrast-enhanced perfusion MR (DSC-MRI), (2) estimate diagnostic accuracy permeability imaging. A prospective 61 patients (40 GBMs 21 metastases) was performed at 3 T DSC-MRI. Normalized rCBV rCBF tumoral (rCBVt, rCBFt), peri-enhancing region (rCBVe, rCBFe), by dividing value tumor (rCBVt/e, rCBFt/e), as well MVL were calculated. Hemodynamic histopathologic variables analyzed statistically Spearman/Pearson correlations. Receiver operating characteristic curve analysis for each variables. rCBVe, rCBFe, significantly greater compared with those metastases. optimal cutoff differentiating 0.80 which implies a sensitivity 95%, specificity 92%, positive predictive 86%, negative 97% rCBVe ratio. We found modest correlation rCBVt rCBFt ratios. measurements are higher than Statistically, both rCBVt/e rCBFt/e useful metastases, supporting hypothesis that can detect infiltration cells region.