Modulation of innate immunity receptors' signaling by micrornas mir-146a and mir-146b
作者： Mark Boldin , David Baltimore , Konstantin Taganov
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摘要: The present disclosure relates to the finding that microRNA-146 plays a role modulating innate immune response. Innate immunity receptor signaling can be modulated by delivery of (miR-146) or antisense miR-146 target cells. In some embodiments, IL-1 associated kinase 1 (IRAK1) and TNF factor 6 (TRAF6) expression levels are downregulated in cell administering oligonucleotide. Modulation system through used treat variety diseases disorders with activation system, such as sepsis Crohn's disease.
lens.org参考文章(69)
David P Bartel, MicroRNAs: Genomics, Biogenesis, Mechanism, and Function Cell. ,vol. 116, pp. 281- 297 ,(2004) , 10.1016/S0092-8674(04)00045-5
S. Akira, H. Isshiki, T. Sugita, O. Tanabe, S. Kinoshita, Y. Nishio, T. Nakajima, T. Hirano, T. Kishimoto, A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. The EMBO Journal. ,vol. 9, pp. 1897- 1906 ,(1990) , 10.1002/J.1460-2075.1990.TB08316.X
Yoshihiro Hirata, Tomoya Ohmae, Wataru Shibata, Shin Maeda, Keiji Ogura, Haruhiko Yoshida, Takao Kawabe, Masao Omata, MyD88 and TNF Receptor-Associated Factor 6 Are Critical Signal Transducers in Helicobacter pylori-Infected Human Epithelial Cells Journal of Immunology. ,vol. 176, pp. 3796- 3803 ,(2006) , 10.4049/JIMMUNOL.176.6.3796
J. Couzin, Small RNAs Make Big Splash Science. ,vol. 298, pp. 2296- 2297 ,(2002) , 10.1126/SCIENCE.298.5602.2296
Diana Sainsbury, Paul Singleton, Dictionary of Microbiology and Molecular Biology ,(1993)
Bo U Curry, Hui Wang, Analysis of microRNA ,(2006)
Silvia Monticelli, K Mark Ansel, Changchun Xiao, Nicholas D Socci, Anna M Krichevsky, To-Ha Thai, Nikolaus Rajewsky, Debora S Marks, Chris Sander, Klaus Rajewsky, Anjana Rao, Kenneth S Kosik, MicroRNA profiling of the murine hematopoietic system Genome Biology. ,vol. 6, pp. 1- 15 ,(2005) , 10.1186/GB-2005-6-8-R71
Muthiah Manoharan, Kallanthottathil G. Rajeev, Venkitasamy Kesavan, Chemically modified oligonucleotides ,(2005)
Christophe Desmet, Philippe Gosset, Bernard Pajak, Didier Cataldo, Mohamed Bentires-Alj, Pierre Lekeux, Fabrice Bureau, Selective Blockade of NF-κB Activity in Airway Immune Cells Inhibits the Effector Phase of Experimental Asthma Journal of Immunology. ,vol. 173, pp. 5766- 5775 ,(2004) , 10.4049/JIMMUNOL.173.9.5766
H. He, K. Jazdzewski, W. Li, S. Liyanarachchi, R. Nagy, S. Volinia, G. A. Calin, C.-g. Liu, K. Franssila, S. Suster, R. T. Kloos, C. M. Croce, A. de la Chapelle, The role of microRNA genes in papillary thyroid carcinoma Proceedings of the National Academy of Sciences. ,vol. 102, pp. 19075- 19080 ,(2005) , 10.1073/PNAS.0509603102