Chemical reaction engineering using molecularly imprinted polymeric catalysts

摘要: Abstract Enzymes play an important role as highly specific catalysts in biotechnology [J. Biotechnol. 66 (1998) 3; Hydrolases Organic Synthesis, Wiley, New York, 1999] well chemical reaction engineering 59 (1997) 11; Trends 13 (7) (1995) 253]. However, the drawbacks of these biomaterials are poor durability and relatively high costs production. Thus, technique molecular imprinting [Bio/Technology 14 (1996) 163; Angew. Chem. Int. Ed. Engl. 34 1812; Anal. Commun. 36 (9) (1999) 327; J. Chromatogr. 781 43] can be applied for generating much more stable polymeric mimics biological enzymes. For this purpose, a transition state analogue (TSA) selected must chosen template [Macromol. Rapid 19 671; Curr. Opin. Biol. 3 759]. The imprint TSA acts like catalytically active centre. This binding site shows its catalytic effect by reducing activation energy reaction. In work presented here, molecularly imprinted polymers have been generated investigated processes, using batch reactors continuously driven equipped with polymers. Parameters such temperature, concentration substrate or volume flow varied, rates measured kinetic data recorded. Based on information, rate constants calculated, relative effects. It is demonstrated that polymer show obvious properties used alternative traditional catalyst materials.