The RT6 (Art2) family of ADP-ribosyltransferases in rat and mouse.

摘要: Recent evidence suggests that a new member of the mono-ADP-ribosyltransferase/NAD glycohydrolase family, RT6, may be important in immune regulation. RT6 is expressed two allelic forms and present on post-thymic T cells rat. RT6-expressing rat have regulatory role, conclusion based their ability to prevent autoimmune diabetes BB model insulin-dependent mellitus. This observation led investigation at molecular biochemical level resulting determination protein exists as both glycosylated non-glycosylated glycosylphosphatidylinositol (GPI)-linked cell surface molecules. like many GPI-linked proteins, can mediate signal transduction events associated with activation, also soluble form circulation. The discovery an NAD auto-ADP-ribosyltransferase ongoing investigations into role enzymatic activity immunoregulatory function RT6+ cells. A homologue termed Rt6, has been identified mouse. Rt6 predominately ADP-ribosyltransferase enzyme determined using simple guanidino compounds (e.g. arginine) ribose acceptors. Abnormalities mouse mRNA are expression autoimmunity. In manuscript, we review recent data RT6/Rt6, discuss potential mechanisms by which cells, perhaps itself,