EGFR-specific T cell frequencies correlate with EGFR expression in head and neck squamous cell carcinoma
作者： Patrick J Schuler , Petra Boeckers , Rainer Engers , Edwin Boelke , Murat Bas
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摘要: In head and neck squamous cell carcinoma (HNSCC), expression levels of the epidermal growth factor receptor (EGFR) correlate with poor prognosis decreased survival rates. As mechanisms responsible for cellular immune response to EGFR in vivo remain unclear, frequency function EGFR-specific cytotoxic T cells (CTL) was determined HNSCC patients. The CTL specific HLA-A2.1-restricted EGFR-derived YLN peptide (YLNTVQPTCV) KLF (KLFGTSGQKT) 16 HLA-A2.1+ patients healthy individuals (NC) by multicolor flow cytometry. Patients' results were correlated obtained immunohistochemistry corresponding tumor sections. Proliferation anti-tumor activity peptide-specific demonstrated vitro stimulation dendritic pulsed peptides. Frequency significantly sections (p = 0.02, r2 0.6). Patients elevated scores (> 7) had a higher than NC low (< 7). from cancer expanded ex produced IFN-γ upon recognition EGFR+ target cells. expressed on induces vivo. Strategies expansion may be important future immunotherapy
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