Immune Responses to Epidermal Growth Factor Receptor (EGFR) and Their Application for Cancer Treatment.
作者： Tetsuro Sasada , Koichi Azuma , Junya Ohtake , Yuki Fujimoto
关键词:
摘要: Epidermal growth factor receptor (EGFR) is a prototypic cell-surface belonging to the ErbB/HER onocogene family. Overexpression or somatic mutations of EGFR have been reported play an important role in tumorigenesis various types epithelial cancers. Therefore, targeting with specific blocking antibodies inhibitors developing for treatment EGFR-associated tumors. Immune responses HER2, another molecule family, well studied, but only limited information on immune cancer has currently available. In this review, we summarized available data and discussed potential clinical importance anti-EGFR EGFR-mediated regulation cancer. Several lines evidence suggest that cellular humoral might be useful as marker and/or target therapy against addition, recent studies critical roles signaling expression checkpoint molecule, programmed death-ligand 1 (PD-L1) tumor cells. Further are warranted clarify impact immunomodulation application treatment.
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Dorte Aa. Olsen, Erik H. Jakobsen, Ivan Brandslund, Quantification of EGFR autoantibodies in the amplification phenomenon of HER2 in breast cancer. Clinical Chemistry and Laboratory Medicine. ,vol. 51, pp. 2325- 2329 ,(2011) , 10.1515/CCLM-2013-0166
Xiaojun Liu, Shuguang Jiang, Chongyun Fang, Shiyu Yang, Devvora Olalere, Edward C. Pequignot, Alexandria P. Cogdill, Na Li, Melissa Ramones, Brian Granda, Li Zhou, Andreas Loew, Regina M. Young, Carl H. June, Yangbing Zhao, Affinity-Tuned ErbB2 or EGFR Chimeric Antigen Receptor T Cells Exhibit an Increased Therapeutic Index against Tumors in Mice Cancer Research. ,vol. 75, pp. 3596- 3607 ,(2015) , 10.1158/0008-5472.CAN-15-0159
Tetsuro Sasada, Akira Yamada, Masanori Noguchi, Kyogo Itoh, Personalized peptide vaccine for treatment of advanced cancer. Current Medicinal Chemistry. ,vol. 21, pp. 2332- 2345 ,(2014) , 10.2174/0929867321666140205132936
Shannon L Maude, Noelle Frey, Pamela A Shaw, Richard Aplenc, David M Barrett, Nancy J Bunin, Anne Chew, Vanessa E Gonzalez, Zhaohui Zheng, Simon F Lacey, Yolanda D Mahnke, Jan J Melenhorst, Susan R Rheingold, Angela Shen, David T Teachey, Bruce L Levine, Carl H June, David L Porter, Stephan A Grupp, None, Chimeric antigen receptor T cells for sustained remissions in leukemia. The New England Journal of Medicine. ,vol. 371, pp. 1507- 1517 ,(2014) , 10.1056/NEJMOA1407222
Esra A. Akbay, Shohei Koyama, Julian Carretero, Abigail Altabef, Jeremy H. Tchaicha, Camilla L. Christensen, Oliver R. Mikse, Andrew D. Cherniack, Ellen M. Beauchamp, Trevor J. Pugh, Matthew D. Wilkerson, Peter E. Fecci, Mohit Butaney, Jacob B. Reibel, Margaret Soucheray, Travis J. Cohoon, Pasi A. Janne, Matthew Meyerson, D. Neil Hayes, Geoffrey I. Shapiro, Takeshi Shimamura, Lynette M. Sholl, Scott J. Rodig, Gordon J. Freeman, Peter S. Hammerman, Glenn Dranoff, Kwok-Kin Wong, Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors Cancer Discovery. ,vol. 3, pp. 1355- 1363 ,(2013) , 10.1158/2159-8290.CD-13-0310
Gao Guo, Ke Gong, Bryan Wohlfeld, Kimmo J. Hatanpaa, Dawen Zhao, Amyn A. Habib, Ligand-Independent EGFR Signaling Cancer Research. ,vol. 75, pp. 3436- 3441 ,(2015) , 10.1158/0008-5472.CAN-15-0989
Patrick J Schuler, Petra Boeckers, Rainer Engers, Edwin Boelke, Murat Bas, Jens Greve, Claudia A Dumitru, Goetz F Lehnerdt, Robert L Ferris, Pedro A Andrade Filho, Sven Brandau, Stephan Lang, Theresa L Whiteside, Thomas K Hoffmann, EGFR-specific T cell frequencies correlate with EGFR expression in head and neck squamous cell carcinoma Journal of Translational Medicine. ,vol. 9, pp. 168- 168 ,(2011) , 10.1186/1479-5876-9-168
John H. Sampson, Amy B. Heimberger, Gary E. Archer, Kenneth D. Aldape, Allan H. Friedman, Henry S. Friedman, Mark R. Gilbert, James E. Herndon, Roger E. McLendon, Duane A. Mitchell, David A. Reardon, Raymond Sawaya, Robert J. Schmittling, Weiming Shi, James J. Vredenburgh, Darell D. Bigner, Immunologic Escape After Prolonged Progression-Free Survival With Epidermal Growth Factor Receptor Variant III Peptide Vaccination in Patients With Newly Diagnosed Glioblastoma Journal of Clinical Oncology. ,vol. 28, pp. 4722- 4729 ,(2010) , 10.1200/JCO.2010.28.6963
Teppei Yamada, Koichi Azuma, Emi Muta, Jintaek Kim, Shunichi Sugawara, Guang Lan Zhang, Satoko Matsueda, Yuri Kasama-Kawaguchi, Yuichi Yamashita, Takuto Yamashita, Kazuto Nishio, Kyogo Itoh, Tomoaki Hoshino, Tetsuro Sasada, EGFR T790M Mutation as a Possible Target for Immunotherapy; Identification of HLA-A*0201-Restricted T Cell Epitopes Derived from the EGFR T790M Mutation PLoS ONE. ,vol. 8, pp. e78389- ,(2013) , 10.1371/JOURNAL.PONE.0078389
Yanna Tang, Wenfeng Fang, Yaxiong Zhang, Shaodong Hong, Shiyang Kang, Yue Yan, Nan Chen, Jianhua Zhan, Xiaobo He, Tao Qin, Ge Li, Wenyi Tang, Peijian Peng, Li Zhang, The association between PD-L1 and EGFR status and the prognostic value of PD-L1 in advanced non-small cell lung cancer patients treated with EGFR-TKIs Oncotarget. ,vol. 6, pp. 14209- 14219 ,(2015) , 10.18632/ONCOTARGET.3694