Immunologic Escape After Prolonged Progression-Free Survival With Epidermal Growth Factor Receptor Variant III Peptide Vaccination in Patients With Newly Diagnosed Glioblastoma
作者： John H. Sampson , Amy B. Heimberger , Gary E. Archer , Kenneth D. Aldape , Allan H. Friedman
关键词: Gene mutation 、 Dacarbazine 、 Temozolomide 、 DNA methylation 、 Mutation 、 Immunology 、 Regulation of gene expression 、 Epidermal growth factor receptor 、 Medicine 、 Immunohistochemistry
摘要: Purpose Immunologic targeting of tumor-specific gene mutations may allow precise eradication neoplastic cells without toxicity. Epidermal growth factor receptor variant III (EGFRvIII )i s a constitutively activated and immunogenic mutation not expressed in normal tissues but widely glioblastoma multiforme (GBM) other neoplasms.
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researchgate.net 参考文章(32)
則雄 荒木, What's going on 放射線 Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, et al; European Organisation for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups; National Cancer Institute of Canada Clinical Trials Group. N Engl J Med. 2005; 352: 987-96. PMID: 15758009.--神経膠腫に対する治療として、放射線治療とテモゾロマイドの併用が世界的な標準的治療となりうることを示唆する論文 Mebio oncology. ,vol. 3, pp. 132- 134 ,(2006)
Oliver Bögler, Motoo Nagane, Frank Coufal, H-J. Su Huang, H-J. Su Huang, Hong Lin, Webster K. Cavenee, A Common Mutant Epidermal Growth Factor Receptor Confers Enhanced Tumorigenicity on Human Glioblastoma Cells by Increasing Proliferation and Reducing Apoptosis Cancer Research. ,vol. 56, pp. 5079- 5086 ,(1996)
Holly M. Martinson, John H. Sampson, Gary E. Archer, Gregory J. Riggins, Chad A. Glazer, Anita Lal, Henry S. Friedman, Mutant Epidermal Growth Factor Receptor Up-Regulates Molecular Effectors of Tumor Invasion Cancer Research. ,vol. 62, pp. 3335- 3339 ,(2002)
Enkhtsetseg Purev, Dewei Cai, Eric Miller, Rolf Swoboda, Ted Mayer, Andres Klein-Szanto, Francesco M. Marincola, Rosemarie Mick, Laszlo Otvos, William Wunner, Brigitte Birebent, Rajasekharan Somasundaram, Carol J. Wikstrand, Darell Bigner, Angela DeMichele, Geza Acs, Jesse A. Berlin, Dorothee Herlyn, Immune Responses of Breast Cancer Patients to Mutated Epidermal Growth Factor Receptor (EGF-RvIII, ΔEGF-R, and de2–7 EGF-R) Journal of Immunology. ,vol. 173, pp. 6472- 6480 ,(2004) , 10.4049/JIMMUNOL.173.10.6472
D R Macdonald, T L Cascino, S C Schold, J G Cairncross, Response criteria for phase II studies of supratentorial malignant glioma. Journal of Clinical Oncology. ,vol. 8, pp. 1277- 1280 ,(1990) , 10.1200/JCO.1990.8.7.1277
A. J. Wong, J. M. Ruppert, S. H. Bigner, C. H. Grzeschik, P. A. Humphrey, D. S. Bigner, B. Vogelstein, Structural alterations of the epidermal growth factor receptor gene in human gliomas Proceedings of the National Academy of Sciences of the United States of America. ,vol. 89, pp. 2965- 2969 ,(1992) , 10.1073/PNAS.89.7.2965
John A Boockvar, Dmitri Kapitonov, Gurpreet Kapoor, Joost Schouten, George J Counelis, Oliver Bogler, Evan Y Snyder, Tracy K McIntosh, Donald M O'Rourke, Constitutive EGFR signaling confers a motile phenotype to neural stem cells Molecular and Cellular Neuroscience. ,vol. 24, pp. 1116- 1130 ,(2003) , 10.1016/J.MCN.2003.09.011
Joseph P. Imperato, Nina A. Paleologos, Nicholas A. Vick, Effects of treatment on long-term survivors with malignant astrocytomas. Annals of Neurology. ,vol. 28, pp. 818- 822 ,(1990) , 10.1002/ANA.410280614
Amy B. Heimberger, Roman Hlatky, Dima Suki, David Yang, Jeff Weinberg, Mark Gilbert, Raymond Sawaya, Kenneth Aldape, Prognostic effect of epidermal growth factor receptor and EGFRvIII in glioblastoma multiforme patients. Clinical Cancer Research. ,vol. 11, pp. 1462- 1466 ,(2005) , 10.1158/1078-0432.CCR-04-1737
Hong Ge, Xiaoqi Gong, Careen K. Tang, Evidence of high incidence of EGFRvIII expression and coexpression with EGFR in human invasive breast cancer by laser capture microdissection and immunohistochemical analysis. International Journal of Cancer. ,vol. 98, pp. 357- 361 ,(2002) , 10.1002/IJC.10224