The effect of MK-801 on cortical spreading depression in the penumbral zone following focal ischaemia in the rat.
作者： R. Gill , P. Andiné , L. Hillered , L. Persson , H. Hagberg
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摘要: Cortical spreading depression (CSD) is a transient of neuronal activity that spreads across the cortical surface. In present studies, we have investigated CSD in penumbral zone following permanent middle cerebral artery (MCA) occlusion rat (n = 16/group), using double-barreled Ca2+ -sensitive microelectrodes. Measurements were made for 3 h each animal. During this time, varying number spontaneous CSDs seen control group (total was 30, with range 0–7/rat). These duration: “small” (∼1 min) and “big” (5–45 CSDs. CSD, extracellular [Ca2+] decreased to 0.11 ± 0.07 mM (mean SD). After h, cortex (penumbral zone) either normal (10/16 rats) or lowered 0.5 (2/16 0.1 (4/16 rats). caudate nucleus (ischaemic core area), all rats had an ∼0.1 when measured after recording period. Neuropathological evaluati...
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