E-cadheringene C-160A promoter polymorphism and risk of non-cardia gastric cancer in a Chinese population
作者： Yan Lu , Yao-Chu Xu , Jing Shen , Rong-Bin Yu , Ju-Yin Niu
关键词:
摘要: AIM: To test the hypothesis that E-cadherin gene (CDH1) C-160A promoter variant genotype is associated with an increased risk for developing gastric cancer. METHODS: In this population-based case-control study of cancer in Jiangsu Province, China, we performed polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to CDH1 206 non-cardia patients and 261 age- sex-matched but unrelated cancer-free controls. RESULTS: The frequencies genotypes CC, CA AA were 57.8%, 36.4% 5.8% gasfric cases, respectively, 58.2%, 34.9% 6.9% controls respectively. distributions not significantly different between cases (P = 0.87 frequency P 0.92 allele frequency). Compared CC genotype, (adjusted odds ratios (OR) 1.15, 95% confidence interval (95% CI) 0.78-1.72 OR 0.90 CI 0.42-2.01 genotype). CONCLUSION: may play a major role etiology Chinese population.
sci-hub.st 参考文章(34)
William M Grady, Joseph Willis, Parry J Guilford, Anita K Dunbier, Tumi T Toro, Henry Lynch, Georgia Wiesner, Kelly Ferguson, Charis Eng, Jae-Gahb Park, Seong-Jin Kim, Sanford Markowitz, None, Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer. Nature Genetics. ,vol. 26, pp. 16- 17 ,(2000) , 10.1038/79120
Parry Guilford, Justin Hopkins, James Harraway, Maybelle McLeod, Ngahiraka McLeod, Pauline Harawira, Huriana Taite, Robin Scoular, Andrew Miller, Anthony E. Reeve, E-cadherin germline mutations in familial gastric cancer Nature. ,vol. 392, pp. 402- 405 ,(1998) , 10.1038/32918
Simon A Gayther, Kylie L Gorringe, Susan J Ramus, David Huntsman, Franco Roviello, Nicola Grehan, Jose C Machado, Enrico Pinto, Raquel Seruca, Kevin Halling, Patrick MacLeod, Steven M Powell, Charles E Jackson, Bruce AJ Ponder, Carlos Caldas, None, Identification of Germ-Line E-cadherin Mutations in Gastric Cancer Families of European Origin Cancer Research. ,vol. 58, pp. 4086- 4089 ,(1998)
Ming-Shiang Wu, Shih-Pei Huang, Yu-Ting Chang, Ming-Tsan Lin, Chia-Tung Shun, Ming-Chu Chang, Hsiu-Po Wang, Chien-Jen Chen, Jaw-Town Lin, Association of the −160 C → a promoter polymorphism of E‐cadherin gene with gastric carcinoma risk Cancer. ,vol. 94, pp. 1443- 1448 ,(2002) , 10.1002/CNCR.10371
Geert Berx, Karl-Friedrich Becker, Heinz Höfler, Frans van Roy, Mutations of the human E‐cadherin (CDH1) gene Human Mutation. ,vol. 12, pp. 226- 237 ,(1998) , 10.1002/(SICI)1098-1004(1998)12:4<226::AID-HUMU2>3.0.CO;2-D
Haixin Lei, Sara Sjöberg-Margolin, Sima Salahshor, Barbro Werelius, Eva Jandáková, Kari Hemminki, Annika Lindblom, Igor Vořechovský, CDH1 mutations are present in both ductal and lobular breast cancer, but promoter allelic variants show no detectable breast cancer risk. International Journal of Cancer. ,vol. 98, pp. 199- 204 ,(2002) , 10.1002/IJC.10176
Timothy R Porter, Frances M Richards, Richard S Houlston, D Gareth R Evans, Janusz A Jankowski, Fiona Macdonald, Gail Norbury, Stewart J Payne, Samantha A Fisher, Ian Tomlinson, Eamonn R Maher, None, Contribution of cyclin d1 (CCND1) and E-cadherin (CDH1) polymorphisms to familial and sporadic colorectal cancer. Oncogene. ,vol. 21, pp. 1928- 1933 ,(2002) , 10.1038/SJ.ONC.1205245
M Takeichi, Cadherin cell adhesion receptors as a morphogenetic regulator Science. ,vol. 251, pp. 1451- 1455 ,(1991) , 10.1126/SCIENCE.2006419
J C Machado, C Oliveira, R Carvalho, P Soares, G Berx, C Caldas, R Seruca, F Carneiro, M Sobrinho-Simöes, E-cadherin gene (CDH1) promoter methylation as the second hit in sporadic diffuse gastric carcinoma Oncogene. ,vol. 20, pp. 1525- 1528 ,(2001) , 10.1038/SJ.ONC.1204234
Kari Hemminki, Yongwen Jiang, Familial and second gastric carcinomas: A nationwide epidemiologic study from Sweden Cancer. ,vol. 94, pp. 1157- 1165 ,(2002) , 10.1002/CNCR.10322