Cutting Edge: Loss of TLR2, TLR4, and TLR5 on Langerhans Cells Abolishes Bacterial Recognition

作者: Angelic M.G. van der Aar , Regien M. R. Sylva-Steenland , Jan D. Bos , Martien L. Kapsenberg , Esther C. de Jong

DOI: 10.4049/JIMMUNOL.178.4.1986

关键词:

摘要: … This reactivity may result from weak TLR2 expression by LCs. However, PGN also triggers … impaired bacterial recognition, we showed that LCs are fully responsive to viruses. However, …

参考文章(33)
Marcel B. M. Teunissen, Gamze Piskin, Sergio di Nuzzo, Regien M. R. Sylva-Steenland, Menno A. de Rie, Jan D. Bos, Ultraviolet B Radiation Induces a Transient Appearance of IL-4+ Neutrophils, Which Support the Development of Th2 Responses Journal of Immunology. ,vol. 168, pp. 3732- 3739 ,(2002) , 10.4049/JIMMUNOL.168.8.3732
Jacques Banchereau, Ralph M. Steinman, Dendritic cells and the control of immunity Nature. ,vol. 392, pp. 245- 252 ,(1998) , 10.1038/32588
Claudia N Renn, David Jesse Sanchez, Maria Teresa Ochoa, Annaliza J Legaspi, Chang-Keun Oh, Philip T Liu, Stephan R Krutzik, Peter A Sieling, Genhong Cheng, Robert L Modlin, None, TLR Activation of Langerhans Cell-Like Dendritic Cells Triggers an Antiviral Immune Response Journal of Immunology. ,vol. 177, pp. 298- 305 ,(2006) , 10.4049/JIMMUNOL.177.1.298
Gamze Piskin, Regien M. R. Sylva-Steenland, Jan D. Bos, Marcel B. M. Teunissen, In Vitro and In Situ Expression of IL-23 by Keratinocytes in Healthy Skin and Psoriasis Lesions: Enhanced Expression in Psoriatic Skin The Journal of Immunology. ,vol. 176, pp. 1908- 1915 ,(2006) , 10.4049/JIMMUNOL.176.3.1908
Frank O. Nestle, Luis Filgueira, Brian J. Nickoloff, Günter Burg, Human dermal dendritic cells process and present soluble protein antigens. Journal of Investigative Dermatology. ,vol. 110, pp. 762- 766 ,(1998) , 10.1046/J.1523-1747.1998.00189.X
Shizuo Akira, Kiyoshi Takeda, Toll-like receptor signalling Nature Reviews Immunology. ,vol. 4, pp. 499- 511 ,(2004) , 10.1038/NRI1391
Rajan M. Thomas, Donald V. Belsito, Ching Huang, Li-zhen Chen, Ilone Ormsby, William J. Simmons, Pamela Cowin, Joellen Shaw, Thomas Doetschman, G. Jeanette Thorbecke, Appearance of Langerhans cells in the epidermis of Tgfb1-/-SCID mice: Paracrine and autocrine effects of transforming growth factor-β1 and -β21 Journal of Investigative Dermatology. ,vol. 117, pp. 1574- 1580 ,(2001) , 10.1046/J.0022-202X.2001.01550.X
Junko Takeuchi, Eiji Watari, Eiji Shinya, Yoshihiko Norose, Misako Matsumoto, Tsukasa Seya, Masahiko Sugita, Seiji Kawana, Hidemi Takahashi, Down-regulation of Toll-like receptor expression in monocyte-derived Langerhans cell-like cells: implications of low-responsiveness to bacterial components in the epidermal Langerhans cells. Biochemical and Biophysical Research Communications. ,vol. 306, pp. 674- 679 ,(2003) , 10.1016/S0006-291X(03)01022-2
Giorgio Napolitani, Andrea Rinaldi, Francesco Bertoni, Federica Sallusto, Antonio Lanzavecchia, Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells. Nature Immunology. ,vol. 6, pp. 769- 776 ,(2005) , 10.1038/NI1223