Is chronic rhinosinusitis caused by persistent respiratory virus infection

摘要: Background Many chronic rhinosinusitis (CRS) patients recall an upper respiratory tract infection as the inciting event of their illness. Viral infections have been shown to cause obstruction osteomeatal complex, which is likely be a critical step in development CRS. There clear overlap between pathogenesis CRS and asthma. Infections with viruses childhood increase risk subsequently developing established asthmatics are associated acute exacerbations. We sought determine whether could detected within sinonasal mucosa using polymerase chain reaction (PCR) techniques. Methods Sinus was sampled from 13 2 normal sinuses. PCR used look for common (parainfluenza 1, 2, 3; syncytial virus [RSV]; human metapneumovirus [hMPV]; adenovirus [ADV]; rhinovirus; coronavirus; bocavirus [BoV]; cytomegalovirus [CMV]; influenza A B). Results No were any samples. Conclusion Persistence unlikely ongoing inflammation The possibility remains that transient viral provides initial inflammatory stimulus. © 2011 ARS-AAOA, LLC.