Fabrication of efavirenz loaded nano-formulation using quality by design (QbD) based approach: Exploring characterizations and in vivo safety
作者： Vishal C. Gurumukhi , Sanjaykumar B. Bari
DOI: 10.1016/J.JDDST.2020.101545
关键词:
摘要: Abstract Quality by design (QbD) approach was practically applied in fabrication of nanostructured lipid carrier (NLC) encapsulating efavirenz (EF) to ensure the quality product. Initially, risk factors were categorized based on priority number (RPN) using identification and assessment tools. A central composite rotatable (CCRD) employed assess influence critical process parameter (CPP) (pressure high pressure homogenizer) material attributes (CMAs) (combination solid oil; combination stabilizers) responses such as particle size, dispersity entrapment efficiency. ANOVA evaluate data for confirmation statistical significance (p
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