Effect of increased vascular pressure on lung fluid balance in unanesthetized sheep.

摘要: In 20 unanesthetized sheep, we measured lung lymph flow and plasma protein concentrations during steady-state base-line conditions elevations of pulmonary microvascular hydrostatic pressure (range 3 to 23 cm H2O). every sheep there was a (average 5.7 +/- 2.5 (SD) ml/hour), demonstrating that net fluid filtration occurred. The lymph-plasma total ratio averaged 0.69 0.05, indicating high osmotic in the interstitial at site. Lymph increased concentration decreased approximately linearly whenever rose. A new condition reached 1-2 hours. difference plasma-to-lymph by half increment (50% negative feedback regulation). Extravascular water content, post-mortem, did not change significantly until more than doubled, large safety factor protects lungs against accumulation normally. major contributions appeared be sensitive efficient pump coupled washout protein. coefficient, whose calculation required many assumptions, 1.64 2.65 ml/(cm H2O times hour) over range studied.