Distinct Clinical and Pathological Features Are Associated with the BRAFT1799A(V600E) Mutation in Primary Melanoma

摘要: The BRAF T1799A mutation encodes V600E that leads to activation of the mitogen-activated protein kinase pathway. This study aimed assess clinico-pathological features primary invasive melanomas containing mutation. Patients ( n =251) with from Australia were interviewed and examined respect their melanoma characteristics risk factors. Independent review pathology, allele-specific PCR for mutation, immunohistochemical staining Ki67, phospho-histone-H3 (PH3) performed. was found in 112 (45%) melanomas. Associations P has associations host phenotype, tumor location, pigmentation. Although implicated control cell cycle, is associated a lower rate proliferation.