Mutations in KIT occur at low frequency in melanomas arising from anatomical sites associated with chronic and intermittent sun exposure

摘要: In melanoma, mutations in KIT are most frequent acral and mucosal subtypes rarely reported cutaneous melanomas particularly those associated with intermittent UV exposure. Conversely arising within chronic sun damaged skin considered to harbour at higher rates. To characterize the frequency of a representative melanoma population, 261 patients from two Australian centres were prospectively screened for exons 11, 13 17 gene. A total 257 had non-acral sites four melanomas. No or ocular analysed. identified five tumours (2% entire cohort) including Two three markers damage as assessed by degree elastosis. remaining cohort, 43% chronically skin. This report confirms that an infrequent both exposed