Cellular Biology of Tubulointerstitial Growth

摘要: The capacity of the kidney to grow has been known for more than 2000 years. Aristotle (384–322 B.C.) was probably first describe that animals born with one can develop normally, and single is enlarged compared kidneys normal two-kidney control (WOLF 1993). In early nineteenth century, French physician Pierre-Francois-Olivier Rayer (1793–1867) reported enlargement renal cortex in diabetes mellitus observed size remnant patients whom missing approaches two healthy individuals (RAYER 1837). also undertook microscopic studies found “if partially disorganized, parts become hypertrophied, resulting a curious mixture atrophic hypertrophic parts” (RItz et al. 1989). Gustav Simon (1824–1876), professor surgery at University Heidelberg Germany, performed unilateral nephrectomy human subjects. question whether compensatory growth solely an increase protein (hypertrophy) or rather caused by proliferation puzzled students long time. famous Viennese pathologist Carl Rokitansky (1804–1878) believed after true hypertrophy all tissue constituents, whereas thought cell number responsible (WOlf However, most these confusing opinions be attributed different ages used degree ablation.