Interaction of Oncogenes with Differentiation Programs

摘要: One recurrent theme in the exploration of function and mechanism action oncogenes their proto-oncogene forebears is to view these genes context normal development. There both direct evidence that can alter expression marker proteins a variety differentiated cell types for developmental regulation many proto-oncogenes. Taken together this leads speculation some proto-oncogenes as regulators differentiation. Unfortunately, our current knowledge mechanisms which control differentiation are rather primitive. In context, focus one fates during development large groups gene products serve distinguish different phenotypes. While process likely share properties with systems regulate individual genes, question more coordination functions, what controls or coordinates regulators, allows them respond signals, nature signals they respond. It questions will have multiplicity answers depend on type under consideration. my belief studies functions provide critical insights underlying mysteries My essential purpose review redefine basic concepts form provides discussion roles intervention by oncogenes.