Plasmodium berghei K173: selection of resistance to naphthoquine in a mouse model.
作者： Hong Wang , Zhu-Chun Bei , Jing-Yan Wang , Wu-Chun Cao
DOI: 10.1016/J.EXPPARA.2010.08.020
关键词:
摘要: Naphthoquine (NQ), as a component of ARCO® which composed NQ and artemisinin, is new 4-aminoquinoline antimalarial synthesized by our institute. Here, naphthoquine-resistant line rodent malaria parasite was selected through exposing Plasmodium berghei Keyberg 173 strain to progressively increased drug pressure. The showed more than 200-fold decreased susceptibility with stable resistance phenotype after 10 serial passages without pressure or when cryopreserved over period 12 months. In cross-resistance assay, the NQ-resistant parasites chloroquine 14.5-fold. These findings imply might be long-term usage in epidemic areas efficacy chloroquine-resistant falciparum should monitored closely.
elsevier.com
sci-hub.se 参考文章(38)
Guan YaYi, Zhang GuoQing, Feng XiaoPing, Tang LinHua, Yao JunMin, Hu Ling, Cai Yue, Liu DeQuan, The polymorphisms of Pfcrt 72-76 in Plasmodium falciparum isolated from China and their relationships with chloroquine resistance. Chinese journal of zoonoses. ,vol. 25, pp. 725- 728 ,(2009)
John E. Hyde, Drug-resistant malaria - an insight. FEBS Journal. ,vol. 274, pp. 4688- 4698 ,(2007) , 10.1111/J.1742-4658.2007.05999.X
Francis W Hombhanje, David Linge, Adolf Saweri, Cynthia Kuanch, Robert Jones, Stephen Toraso, Jacobed Geita, Andrew Masta, Isi Kevau, Gilbert Hiawalyer, Mathias Sapuri, Artemisinin-naphthoquine combination (ARCO™) therapy for uncomplicated falciparum malaria in adults of Papua New Guinea: A preliminary report on safety and efficacy Malaria Journal. ,vol. 8, pp. 196- 196 ,(2009) , 10.1186/1475-2875-8-196
Thein Tun, Hla Soe Tint, Khin Lin, Thar Tun Kyaw, Moe Kyaw Myint, Win Khaing, Zaw Win Tun, Efficacy of oral single dose therapy with artemisinin-naphthoquine phosphate in uncomplicated falciparum malaria. Acta Tropica. ,vol. 111, pp. 275- 278 ,(2009) , 10.1016/J.ACTATROPICA.2009.05.007
Rina P. M. Wong, Dulcie Lautu, Livingstone Tavul, Sara L. Hackett, Peter Siba, Harin A. Karunajeewa, Kenneth F. Ilett, Ivo Mueller, Timothy M. E. Davis, In vitro sensitivity of Plasmodium falciparum to conventional and novel antimalarial drugs in Papua New Guinea. Tropical Medicine & International Health. ,vol. 15, pp. 342- 349 ,(2010) , 10.1111/J.1365-3156.2009.02463.X
Heng Yan Qu, Hong Zhi Gao, Guang Tao Hao, Yuan Yuan Li, Hai Yan Li, Jin Chao Hu, Xiao Fang Wang, Wei Li Liu, Ze Yuan Liu, Single-Dose Safety, Pharmacokinetics, and Food Effects Studies of Compound Naphthoquine Phosphate Tablets in Healthy Volunteers The Journal of Clinical Pharmacology. ,vol. 50, pp. 1310- 1318 ,(2010) , 10.1177/0091270009356296
Alexis Nzila, Inhibitors of de novo folate enzymes in Plasmodium falciparum. Drug Discovery Today. ,vol. 11, pp. 939- 944 ,(2006) , 10.1016/J.DRUDIS.2006.08.003
A. F. Cowman, D. Galatis, J. K. Thompson, Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdr1 gene and cross-resistance to halofantrine and quinine. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 91, pp. 1143- 1147 ,(1994) , 10.1073/PNAS.91.3.1143
Stéphane Picot, Piero Olliaro, Frédérique de Monbrison, Anne-Lise Bienvenu, Ric N Price, Pascal Ringwald, A systematic review and meta-analysis of evidence for correlation between molecular markers of parasite resistance and treatment outcome in falciparum malaria Malaria Journal. ,vol. 8, pp. 89- 103 ,(2009) , 10.1186/1475-2875-8-89
Simon J. Foote, Jennifer K. Thompson, Alan F. Cowman, David J. Kemp, Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of P. falciparum. Cell. ,vol. 57, pp. 921- 930 ,(1989) , 10.1016/0092-8674(89)90330-9