Genesis of antinuclear antibody in NZB-W mice: role of genetic factors and of viral infections.

摘要: Antinuclear antibodies could be induced in young NZB/W mice long before the natural occurrence of such by immunization with heat denatured DNA coupled to methylated bovine serum albumin (DNA m BSA). While induction antinuclear was possible several strains (NZB/W, A/J, DBA/2, CBA and AKR), had far highest titre antibody. A genetic determination this immune hyperreactivity suggested study parental strains. The NZW which have a low incidence spontaneously occurring antibody made as much upon BSA did mice, while NZB develop naturally moderate responded relatively poorly immunization. It seemed that native might inherited from parent, antigenic stimulus calling forth anti-DNA response transmitted parent. source viral infection caused leukemia virus found liberate unusual amounts or kinds host nuclear antigens provide nucleic acid antigens. In support this, neonatal Polyoma markedly enhanced their response. Also, thymectomy predisposes reduced resistance also formation. And finally, Statolon treatment designed increase maintain interferon levels both normal thymectomized