Presence of pluripotent CD133+ cells correlates with malignancy of gliomas

摘要: Abstract Background Presence of CD133+ cancer stem cells has been demonstrated within glioblastoma multiforme (GBM), the most malignant phenotype gliomas (WHO grade IV). Since GBM frequently develops from low II) we assessed a possible qualitative or quantitative correlation and glioma to get new insights in gliomagenesis. Results The amount bulk tumor mass, analyzed by immunostaining Western blotting, showed clear with (WHO° II, III Most were arranged clusters associated vessels. Protein analysis revealed high cellular coexpression CD133 Musashi-I but not CD34 indicating neural, i.e. local origin these cells. In vitro, no differences cell properties concerning self-renewal multi-lineage differentiation have found for isolated different grades. Conclusions These findings indicate solely presence neural tumors supporting concept dependent