Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14.

作者: Elise Ruark , , Sheila Seal , Heather McDonald , Feng Zhang

DOI: 10.1038/NG.2635

关键词:

摘要: Testicular germ cell tumor (TGCT) is the most common cancer in young men and notable for its high familial risks. So far, six loci associated with TGCT have been reported. From genome-wide association study (GWAS) analysis of 307,291 SNPs 986 cases 4,946 controls, we selected follow-up 694 SNPs, which genotyped a further 1,064 10,082 controls from UK. We identified at nine new (1q22, 1q24.1, 3p24.3, 4q24, 5q31.1, 8q13.3, 16q12.1, 17q22 21q22.3) showing (P < 5 × 10(-8)), together account an additional 4-6% risk TGCT. The include genes plausibly related to development. PRDM14, essential early specification, DAZL, required regulation Furthermore, PITX1, regulates TERT expression third TGCT-associated locus implicated telomerase regulation.

参考文章(48)
P. Jeremy Wang, John R. McCarrey, Fang Yang, David C. Page, An abundance of X-linked genes expressed in spermatogonia Nature Genetics. ,vol. 27, pp. 422- 426 ,(2001) , 10.1038/86927
Charles C Chung, Peter A Kanetsky, Zhaoming Wang, Michelle A T Hildebrandt, Roelof Koster, Rolf I Skotheim, Christian P Kratz, Clare Turnbull, Victoria K Cortessis, Anne C Bakken, D Timothy Bishop, Michael B Cook, R Loren Erickson, Sophie D Fosså, Kevin B Jacobs, Larissa A Korde, Sigrid M Kraggerud, Ragnhild A Lothe, Jennifer T Loud, Nazneen Rahman, Eila C Skinner, Duncan C Thomas, Xifeng Wu, Meredith Yeager, Fredrick R Schumacher, Mark H Greene, Stephen M Schwartz, Katherine A McGlynn, Stephen J Chanock, Katherine L Nathanson, Meta-analysis identifies four new loci associated with testicular germ cell tumor Nature Genetics. ,vol. 45, pp. 680- 685 ,(2013) , 10.1038/NG.2634
Maria Teresa Landi, Nilanjan Chatterjee, Kai Yu, Lynn R. Goldin, Alisa M. Goldstein, Melissa Rotunno, Lisa Mirabello, Kevin Jacobs, William Wheeler, Meredith Yeager, Andrew W. Bergen, Qizhai Li, Dario Consonni, Angela C. Pesatori, Sholom Wacholder, Michael Thun, Ryan Diver, Martin Oken, Jarmo Virtamo, Demetrius Albanes, Zhaoming Wang, Laurie Burdette, Kimberly F. Doheny, Elizabeth W. Pugh, Cathy Laurie, Paul Brennan, Rayjean Hung, Valerie Gaborieau, James D. McKay, Mark Lathrop, John McLaughlin, Ying Wang, Ming-Sound Tsao, Margaret R. Spitz, Yufei Wang, Hans Krokan, Lars Vatten, Frank Skorpen, Egil Arnesen, Simone Benhamou, Christine Bouchard, Andres Metsapalu, Tonu Vooder, Mari Nelis, Kristian Välk, John K. Field, Chu Chen, Gary Goodman, Patrick Sulem, Gudmar Thorleifsson, Thorunn Rafnar, Timothy Eisen, Wiebke Sauter, Albert Rosenberger, Heike Bickeböller, Angela Risch, Jenny Chang-Claude, H. Erich Wichmann, Kari Stefansson, Richard Houlston, Christopher I. Amos, Joseph F. Fraumeni, Sharon A. Savage, Pier Alberto Bertazzi, Margaret A. Tucker, Stephen Chanock, Neil E. Caporaso, A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma. American Journal of Human Genetics. ,vol. 85, pp. 679- 691 ,(2009) , 10.1016/J.AJHG.2009.09.012
Freddie Bray, Jacques Ferlay, Susan S Devesa, Katherine A McGlynn, Henrik Møller, Interpreting the international trends in testicular seminoma and nonseminoma incidence. Nature Clinical Practice Urology. ,vol. 3, pp. 532- 543 ,(2006) , 10.1038/NCPURO0606
Peter A Kanetsky, Nandita Mitra, Saran Vardhanabhuti, Mingyao Li, David J Vaughn, Richard Letrero, Stephanie L Ciosek, David R Doody, Lauren M Smith, JoEllen Weaver, Anthony Albano, Chu Chen, Jacqueline R Starr, Daniel J Rader, Andrew K Godwin, Muredach P Reilly, Hakon Hakonarson, Stephen M Schwartz, Katherine L Nathanson, Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer. Nature Genetics. ,vol. 41, pp. 811- 815 ,(2009) , 10.1038/NG.393
Simon Myers, Leonardo Bottolo, Colin Freeman, Gil McVean, Peter Donnelly, A Fine-Scale Map of Recombination Rates and Hotspots Across the Human Genome Science. ,vol. 310, pp. 321- 324 ,(2005) , 10.1126/SCIENCE.1117196
Jingling Jin, Nange Jin, Huili Zheng, Seungil Ro, Dora Tafolla, Kenton M. Sanders, Wei Yan, Catsper3 and Catsper4 Are Essential for Sperm Hyperactivated Motility and Male Fertility in the Mouse Biology of Reproduction. ,vol. 77, pp. 37- 44 ,(2007) , 10.1095/BIOLREPROD.107.060186
Rosalind A Eeles, Ali Amin Al Olama, Sara Benlloch, Edward J Saunders, Daniel A Leongamornlert, Malgorzata Tymrakiewicz, Maya Ghoussaini, Craig Luccarini, Joe Dennis, Sarah Jugurnauth-Little, Tokhir Dadaev, David E Neal, Freddie C Hamdy, Jenny L Donovan, Ken Muir, Graham G Giles, Gianluca Severi, Fredrik Wiklund, Henrik Gronberg, Christopher A Haiman, Fredrick Schumacher, Brian E Henderson, Loic Le Marchand, Sara Lindstrom, Peter Kraft, David J Hunter, Susan Gapstur, Stephen J Chanock, Sonja I Berndt, Demetrius Albanes, Gerald Andriole, Johanna Schleutker, Maren Weischer, Federico Canzian, Elio Riboli, Tim J Key, Ruth C Travis, Daniele Campa, Sue A Ingles, Esther M John, Richard B Hayes, Paul DP Pharoah, Nora Pashayan, Kay-Tee Khaw, Janet L Stanford, Elaine A Ostrander, Lisa B Signorello, Stephen N Thibodeau, Dan Schaid, Christiane Maier, Walther Vogel, Adam S Kibel, Cezary Cybulski, Jan Lubinski, Lisa Cannon-Albright, Hermann Brenner, Jong Y Park, Radka Kaneva, Jyotsna Batra, Amanda B Spurdle, Judith A Clements, Manuel R Teixeira, Ed Dicks, Andrew Lee, Alison M Dunning, Caroline Baynes, Don Conroy, Melanie J Maranian, Shahana Ahmed, Koveela Govindasami, Michelle Guy, Rosemary A Wilkinson, Emma J Sawyer, Angela Morgan, David P Dearnaley, Alan Horwich, Robert A Huddart, Vincent S Khoo, Christopher C Parker, Nicholas J Van As, Christopher J Woodhouse, Alan Thompson, Tim Dudderidge, Chris Ogden, Colin S Cooper, Artitaya Lophatananon, Angela Cox, Melissa C Southey, John L Hopper, Dallas R English, Markus Aly, Jan Adolfsson, Jiangfeng Xu, Siqun L Zheng, Meredith Yeager, Rudolf Kaaks, W Ryan Diver, Mia M Gaudet, Mariana C Stern, Roman Corral, Amit D Joshi, Ahva Shahabi, Tiina Wahlfors, Teuvo LJ Tammela, Anssi Auvinen, Jarmo Virtamo, Peter Klarskov, Børge G Nordestgaard, M Andreas Røder, Sune F Nielsen, Stig E Bojesen, Afshan Siddiq, Liesel M FitzGerald, Suzanne Kolb, Erika M Kwon, Danielle M Karyadi, William J Blot, Wei Zheng, Qiuyin Cai, Shannon K McDonnell, Antje E Rinckleb, Bettina Drake, Graham Colditz, Dominika Wokolorczyk, Robert A Stephenson, Craig Teerlink, Heiko Muller, Dietrich Rothenbacher, Thomas A Sellers, Hui-Yi Lin, Chavdar Slavov, Vanio Mitev, Felicity Lose, Srilakshmi Srinivasan, Sofia Maia, Paula Paulo, Ethan Lange, Kathleen A Cooney, Antonis C Antoniou, Daniel Vincent, François Bacot, Daniel C Tessier, COGS–Cancer Research UK GWAS–ELLIPSE (part of GAME-ON) Initiative, Australian Prostate Cancer Bioresource, UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology, UK ProtecT (Prostate testing for cancer and Treatment) Study Collaborators, PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium, Zsofia Kote-Jarai, Douglas F Easton, None, Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array Nature Genetics. ,vol. 45, pp. 385- 391 ,(2013) , 10.1038/NG.2560
Kazuki Kurimoto, Masashi Yamaji, Yoshiyuki Seki, Mitinori Saitou, Specification of the germ cell lineage in mice: a process orchestrated by the PR-domain proteins, Blimp1 and Prdm14. Cell Cycle. ,vol. 7, pp. 3514- 3518 ,(2008) , 10.4161/CC.7.22.6979