Neural fate decisions mediated by combinatorial regulation of Hes1 and miR-9

摘要: In the nervous system, Hes1 shows an oscillatory manner in neural progenitors but a persistent one neurons. Many models involving have been provided for study of differentiation few them take role microRNA into account. It is known that microRNA, miR-9, plays crucial roles modulating oscillations. However, miR-9 controlling oscillations and inducing transition between different cell fates still need to be further explored. Here we provide mathematical model show interaction Hes1, with aim understanding how are produced, they controlled, further, terminated. Based on experimental findings, demonstrates essential regulating dynamics system. particular, suggests balance important choice progenitor maintenance differentiation. addition, synergistic (or antagonistic) effects several regulations investigated so as elucidate combinatorial regulation decision-making. Our provides qualitative mechanism process fate decisions regulated by miR-9.