Clinicopathologic and Molecular Characteristics of Mesonephric Adenocarcinoma Arising From the Uterine Body.

摘要: Mesonephric adenocarcinoma (MNAC) is a rare tumor of the female genital tract mainly occurring in uterine cervix. To date, only few cases MNAC arising from body (UB-MNAC) have been reported. The clinicopathologic and molecular characteristics UB-MNAC remain unknown. In this study, we investigated clinical, histopathologic, immunohistochemical, genetic features UB-MNAC. total, 11 were included. Six patients developed metastatic disease, most commonly lungs (5/6). Histopathologically, was characterized by an admixture tubular, glandular, papillary, retiform, glomeruloid, sex cord-like, comedonecrosis-like architectural patterns. Three adverse pathologic characteristics, including advanced International Federation Gynecology Obstetrics stage, high mitotic activity, presence lymphovascular invasion, independent factors predicting development metastasis. All positive for GATA-binding protein 3 paired box 2 expression showed wild-type p53, patchy p16, preserved PTEN expression, as indicated immunohistochemistry. Next-generation sequencing using 12 samples (11 primary tumors 1 tumor) revealed 42 single nucleotide variations 16 genes, mostly KRAS (10/12) ARID1A (9/12). Copy number variation found genomic regions, consisted 57 gains 10 losses, with 1q gain (11/12) being prevalent. conclusion, displays aggressive biological behavior, tendency to metastasize lungs. Adverse reflect nature Distinct include frequent somatic mutations 1q.