EGFR overexpression in canine primary lung cancer: pathogenetic implications and impact on survival.
作者： S. Sabattini , F. R. Mancini , L. Marconato , B. Bacci , F. Rossi
DOI: 10.1111/VCO.12002
关键词:
摘要: This study reports the main clinicopathological features of primary lung cancer (PLC) in 37 dogs, with special regard to pathogenetic and prognostic role epidermal growth factor receptor (EGFR) overexpression. For each case following characteristics were evaluated: tumour-node-metastasis (TNM) stage, tumour histotype, histological grade, mitotic activity immunohistochemical expression EGFR. In samples available normal tissue, amount background anthracosis was also measured by image analysis. 27 tumours (73%) a variable number cells (20-100%) stained positively for The proportion EGFR-positive significantly higher cases anthracosis, correlated percentage positive cells. Additionally, trend towards shortened survival high EGFR group observed. These findings suggest an involvement signalling pathway canine PLC, negative significance protein overexpression its potential implication air pollution carcinogenesis.
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