Immunohistochemical Evidence of Autocrine Growth Factors in Adenocarcinoma of the Human Lung
作者： Tetsuya Mitsudomi , Masahiro Tateishi , Teruyoshi Ishida , Keizo Sugimachi , Satoshi Kaneko
DOI: 10.11501/3078977
关键词:
摘要: We immunohistochemically examined 131 primary human lung adenocarcinomas for the possible presence of autocrine factors. Transforming growth factor alpha (TGF alpha) and epidermal (EGF) were considered factors with receptor (EGFR) as receptor. Of these tumors, 87 (66%) showed a high expression TGF alpha, 66 (50%) EGF, 55 (42%) positive EGFR reactivity. In EGFR-positive cases, 5-year survival rates patients low 36% 85%, respectively (P less than 0.05). The EGF 25% 77%, contrast, in EGFR-negative there was no statistical difference between either or EGF. Because mechanisms are present adenocarcinoma lung, events may contribute to clarification tumor development, perhaps even better prognosis.
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sci-hub.st 参考文章(15)
Stanley Cohen, Isolation of a Mouse Submaxillary Gland Protein Accelerating Incisor Eruption and Eyelid Opening in the New-born Animal Journal of Biological Chemistry. ,vol. 237, pp. 1555- 1562 ,(1962) , 10.1016/S0021-9258(19)83739-0
A B Schreiber, T A Libermann, I Lax, Y Yarden, J Schlessinger, Biological role of epidermal growth factor-receptor clustering. Investigation with monoclonal anti-receptor antibodies. Journal of Biological Chemistry. ,vol. 258, pp. 846- 853 ,(1983) , 10.1016/S0021-9258(18)33127-2
John M. Taylor, William M. Mitchell, Stanley Cohen, Epidermal Growth Factor Journal of Biological Chemistry. ,vol. 247, pp. 5928- 5934 ,(1972) , 10.1016/S0021-9258(19)44847-3
Jordan U. Gutterman, David V. Goeddel, Richard D. Williams, Axel Ullrich, Rik Derynck, Wendy H. Berger, Timothy S. Bringman, Synthesis of Messenger RNAs for Transforming Growth Factors α and β and the Epidermal Growth Factor Receptor by Human Tumors Cancer Research. ,vol. 47, pp. 707- 712 ,(1987)
Clifton F. Mountain, A new international staging system for lung cancer Chest. ,vol. 89, pp. 225- 233 ,(1986) , 10.1378/CHEST.89.4_SUPPLEMENT.225S
E. L. Kaplan, Paul Meier, Nonparametric Estimation from Incomplete Observations Springer Series in Statistics. ,vol. 53, pp. 319- 337 ,(1992) , 10.1007/978-1-4612-4380-9_25
Robert Shields, Growth factors for tumours. Nature. ,vol. 272, pp. 670- 671 ,(1978) , 10.1038/272670A0
Fred H. Reynolds, George J. Todaro, Charlotte Fryling, John R. Stephenson, Human transforming growth factors induce tyrosine phosphorylation of EGF receptors Nature. ,vol. 292, pp. 259- 262 ,(1981) , 10.1038/292259A0
David C. Lee, Timothy M. Rose, Nancy R. Webb, George J. Todaro, Cloning and sequence analysis of a cDNA for rat transforming growth factor- α Nature. ,vol. 313, pp. 489- 491 ,(1985) , 10.1038/313489A0
Michael B. Sporn, Anita B. Roberts, Autocrine growth factors and cancer. Nature. ,vol. 313, pp. 745- 747 ,(1985) , 10.1038/313745A0