LexA Regulatory System

摘要: Organisms have evolved gene regulatory systems to cope with stress. To maintain the structural and functional integrity of their genomes after damage due environmental or metabolic assaults, bacteria mount a program expression known as ‘SOS response’. Induction this response requires repressor, LexA protein, an inducer, recombinase A (RecA) protein. In Escherichia coli , upon DNA damage, RecA stimulates cleavage inducing approximately 1% genes. The coordinated these genes orchestrates complex repair, which can also result in mutations genetic exchange that facilitate bacterial evolution. some bacteria, SOS modulates virulence factor induce formation dormant cells are highly tolerant antibiotics.