‘No-touch’ saphenous vein harvesting improves graft performance in patients undergoing coronary artery bypass surgery: A journey from bedside to bench

摘要: The saphenous vein is the most commonly used conduit in patients undergoing coronary artery bypass surgery yet its patency inferior to internal thoracic artery. Vascular damage inflicted when using conventional harvesting techniques affects structure. Endothelial denudation associated with early graft failure while of outermost vessel layers has adverse long-term effects on performance. While many vitro and vivo experimental studies aimed at improving have been performed date no significant 'bench bedside' advances made. Among strategies employed use pharmacological agents, gene targeting external stents. A 'no-touch' technique, where removed minimal trauma normal architecture preserved, produces a superior long term comparable Interestingly, are repairing or replacing those regions damaged conventionally. 'No-touch' data published 5years ago. Here we describe 'bedside bench' situation mechanisms underlying improved performance 'no touch' grafts studied laboratory.