Absence of Common Somatic Alterations in Genes on 1p and 19q in Oligodendrogliomas
作者： Linda B. Bralten , Stephan Nouwens , Christel Kockx , Lale Erdem , Casper C. Hoogenraad
DOI: 10.1371/JOURNAL.PONE.0022000
关键词:
摘要: A common and histologically well defined subtype of glioma are the oligodendroglial brain tumors. Approximately 70% all oligodendrogliomas have a combined loss entire 1p 19q chromosomal arms. This remarkably high frequency suggests that remaining arms harbor yet to be identified tumor suppressor genes. Identification these causal genetic changes in is important because they form direct targets for treatment. In this study we therefore performed targeted resequencing exons, microRNAs, splice sites promoter regions residing on 7 4 matched controls. Only one missense mutation was single sample ARHGEF16 gene. lies within- disrupts conserved PDZ binding domain. No similar mutations or deletions were found larger set oligodendrogliomas. The absence somatic within genes located three out four samples indicates no additional "second hit" required drive oncogenic transformation either arm.
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