Overexpressions of DLL4 and CD105 are Associated with Poor Prognosis of Patients with Pancreatic Ductal Adenocarcinoma.
作者： Liangjing Zhou , Leilai Yu , Guoping Ding , Wenchao Chen , Sixin Zheng
DOI: 10.1007/S12253-015-9937-4
关键词:
摘要: The aim of this study was to investigate the expression Delta-like ligand 4(DLL4) and Endoglin(CD105) labeled microvessel density(MVD) in pancreatic ductal adenocarcinoma (PDAC) evaluate their correlation with major clinicopathologic features patients’ survival. Forty-two cancer 20 normal tissues were included study. Immunohistochemical staining employed assess level DLL4 both tumor cells stromal vascular endothelial cells, as well CD105 which used determine MVD. relationships parameters clinical outcome evaluated. Both CD105-labeled observed highly immunostained PDAC cases, high positively correlated Moreover, significantly associated histological grade, node stage TNM not only but also stroma; while stage, distant metastasis. In univariant analysis, patients tended poorer overall overexpressed a large proportion PDAC. MVD, indicating may involved angiogenesis. addition, poor survival
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