Disruption of Cell Cycle Machinery in Pancreatic Cancer

摘要: This chapter discusses the role of cell cycle machinery in initiation and progression pancreatic cancer. Normal cells—their types, organization, functions—are first described to characterize environment which cellular transformation tumor expansion occurs. The epidemiology histology cancer is then briefly presented emphasize urgent need for earlier diagnosis more effective treatments. Current efforts towards this goal are focused on understanding disease at molecular level, so hallmarks cancerous cells discussed with respect model development. Because pancreas composed various types different genetic backgrounds regulatory systems, identifying originates utmost importance. Molecular mechanisms normal proliferative control that by they disrupted can be appreciated. Particular attention paid how signaling transduction pathways cooperate make fate decisions Restriction point. analysis sets stage evaluating initiating concludes arguing alterations associated indicate play a central development progression.