In vivo regulation of the entry into M-phase: initial activation and nuclear translocation of cyclin B/Cdc2

摘要: The cyclin B/Cdc2 complex, Cdc2 kinase governs M-phase. Although the intracomplex modification for its activation in vitro has been described extensively, regulation vivo is not so well explained far. In this article, we will focus on intracellular of activity, particular, how it initially activated vivo, nuclear translocation executed specifically at onset M-phase, and are coordinated cell. These concerted regulations may determine appropriate timing initiation