Spatially segregated feedforward and feedback neurons support differential odor processing in the lateral entorhinal cortex

摘要: The lateral entorhinal cortex (LEC) computes and transfers olfactory information from the bulb to hippocampus. Here we established LEC connectivity upstream downstream brain regions understand how processes information. We report that, in layer II (LII), reelin- calbindin-positive (RE(+) CB(+)) neurons constitute two major excitatory cell types that are electrophysiologically distinct differentially connected. RE(+) convey hippocampus, while CB(+) project bulb. In vivo calcium imaging revealed responded with higher selectivity specific odors than GABAergic neurons. At population level, odor discrimination was significantly better for neurons, lowest Thus, identified LII of anatomically functionally neuronal subpopulations engage feedforward feedback signaling during processing.