Six month inhalation studies of pirbuterol acetate aerosol in the beagle dog and squirrel monkey.

摘要: Abstract Groups of Beagle dogs and Squirrel monkeys were exposed to aerosols pirbuterol acetate, a new bronchodilator at doses 0, 200, 400 800 μg pirbuterol/kg body weight daily for 6 months. Each group consisted 4 or per sex. Dogs by face mask head only in manifold. Plasma drug concentrations indicated that expected levels exposure achieved both species. No significant alterations revealed physical appearance weights, hematological blood biochemical analyses, urinalyses, ophthalmoscopy, assessment cardiovascular status, pulmonary function gross histopathology. Examination the respiratory tract showed no morphological changes could be attributed acetate inhalation.