Antitumor antibodies in the treatment of cancer: Fc receptors link opsonic antibody with cellular immunity.
作者： Raphael Clynes
DOI: 10.1016/J.HOC.2006.02.010
关键词:
摘要: Engineered antibody therapeutics have provided new treatment options in cancer. Genetic evidence man and the mouse suggests that Fc receptor (FcR) engagement contributes mechanistically to therapeutic activity of naked antibodies. Preferential activation activating FcRs limited inhibitory enhance tumor responses models. Thus, engineered domains with favorable affinities for specific FcR types may prove be clinically superior.
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