摘要: Thirty-seven Japanese autopsy cases with diffuse Lewy body disease (DLBD) were reviewed from a clinicopathological viewpoint. Based on the neuropathological finding of whether or not many concomitant senile plaques (SPs) and/or neurofibrillary tangles (NFTs) are present, DLBD is divided into two forms: common form and pure form. In only numerous bodies but also SPs NFTs found in cerebral cortex, whereas there no few changes. Of 37 cases, 28 had form, 9 DLBD. all shown progressive cortical dementia presenile period. About 60% began memory disturbance, while 25% showed Parkinson's Shy-Drager syndrome initially. syndrome, consisting mainly muscular rigidity akinesia, was usually marked later stage, although 8 (28.6%) which parkinsonian symptoms detected even terminal stage. On other hand, almost juvenile followed by dementia, one case mild syndrome. These compared reported Western countries.
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