FSH and ovarian response: spontaneous recovery of pituitary-ovarian activity during the pill-free period vs. exogenous recombinant FSH during high-dose combined oral contraceptives.

摘要: Objective Compare spontaneous recovery of pituitary-ovarian activity during the pill-free period following correct use low-dose oral contraceptives and subsequent ovarian function administration exogenous recombinant FSH (recFSH) after switching to continued Lyndiol® (2.5 mg lynestrenol + 0.05 ethinyl-oestradiol) medication. Design Prospective randomized group-comparative single-centre study. Following monitoring (week 1) treatment with (for a total 5 weeks) all subjects were randomly allocated one four groups receiving daily injections for 1 week [75 150 225 IU recFSH or purified urinary (uFSH)] fourth use. Patients Thirty-six healthy volunteers aged 18-39 years prestudy contraceptive at least 3 months cycle length between 24 35 days. Measurements Serum LH oestradiol (E(-2)) concentrations as well transvaginal ultrasound assessment number diameter follicles > 2 mm used monitor pituitary function. Results At start medication 67% women presented levels 10 was observed. Initial correlated (P had emerged in subject only. During first days seven (19%) eventually showed follicle mm. combined remained completely suppressed (= IU/I) studied. size increased increasing doses dose-dependent manner. E(-2)levels low ( still increased. Conclusions We have confirmed that dominant are present end pill- free resumption pill intake. Once arose did not reduce diameters. One reduces observed weeks pills. resulted growth despite extremely levels. E(-2) secretion (56 ± 51 pmol/l) occurred limited variable extent along serum concentrations. Recovery is comparable dynamics 7 75-150 IU/I recFSH. (authors)