Evaluation of three microhaplotypes in individual identification and ancestry inference.
作者： Shunlan Wang , Yingai Zhang , Shufang Zhang , Xiaohong Wen , Haowei He
DOI: 10.1016/J.FORSCIINT.2021.110681
关键词:
摘要: Microhaplotype as an emerging genetic marker has attracted more attention in forensic field. The purpose of this study was to evaluate the potential microhaplotypes individual identification and ancestry inference Chinese Hainan Li 26 1000 G populations. Three were genotyped from 100 individuals using Agena MassARRAY. Moreover, 2504 populations (1000 Genomes Project database) enrolled. genotypes frequencies each population calculated by Plink software. We used Structure, Arlequin, MEGA6 software analyze structure, differentiation background difference, respectively. parameters these Modified Powerstats distribution three elaborated high diversities among had a close relationship with EAS structure analysis. No observed between CHS Fst NJ tree showed that is most similar. average heterozygosity (HE), probability match (PM), power discrimination (PD), exclusion (PE) polymorphism information content (PIC) values for 27 0.535, 0.497, 0.465, 0.325, 0.481, In conclusion, our results revealed markers Future studies are needed confirm larger samples select much higher efficacy microhaplotypes.
sci-hub.st 参考文章(29)
Hui Wang, Jing Zhu, Nan Zhou, Youjing Jiang, Li Wang, Wang He, Duo Peng, Qin Su, Jiong Mao, Dan Chen, Weibo Liang, Lin Zhang, NGS technology makes microhaplotype a potential forensic marker Forensic Science International: Genetics Supplement Series. ,vol. 5, ,(2015) , 10.1016/J.FSIGSS.2015.09.093
Kenneth K. Kidd, Judith R. Kidd, William C. Speed, Rixun Fang, Manohar R. Furtado, F.C.L. Hyland, Andrew J. Pakstis, Expanding data and resources for forensic use of SNPs in individual identification Forensic Science International-genetics. ,vol. 6, pp. 646- 652 ,(2012) , 10.1016/J.FSIGEN.2012.02.012
Jianye Ge, Bruce Budowle, John V. Planz, Ranajit Chakraborty, Haplotype block: a new type of forensic DNA markers International Journal of Legal Medicine. ,vol. 124, pp. 353- 361 ,(2010) , 10.1007/S00414-009-0400-5
Kenneth K. Kidd, Andrew J. Pakstis, William C. Speed, Robert Lagacé, Joseph Chang, Sharon Wootton, Eva Haigh, Judith R. Kidd, Current sequencing technology makes microhaplotypes a powerful new type of genetic marker for forensics. Forensic Science International-genetics. ,vol. 12, pp. 215- 224 ,(2014) , 10.1016/J.FSIGEN.2014.06.014
Erica L. Romsos, Peter M. Vallone, Rapid PCR of STR markers: Applications to human identification. Forensic Science International-genetics. ,vol. 18, pp. 90- 99 ,(2015) , 10.1016/J.FSIGEN.2015.04.008
Nakahara Hiroaki, Fujii Koji, Kitayama Tetsushi, Sekiguchi Kazumasa, Nakanishi Hiroaki, Saito Kazuyuki, Approaches for identifying multiple-SNP haplotype blocks for use in human identification. Legal Medicine. ,vol. 17, pp. 415- 420 ,(2015) , 10.1016/J.LEGALMED.2015.06.003
K.K. Kidd, A.J. Pakstis, W.C. Speed, R. Lagace, J. Chang, S. Wootton, N. Ihuegbu, Microhaplotype loci are a powerful new type of forensic marker Forensic Science International: Genetics Supplement Series. ,vol. 4, ,(2013) , 10.1016/J.FSIGSS.2013.10.063
Andrew J Pakstis, Rixun Fang, Manohar R Furtado, Judith R Kidd, Kenneth K Kidd, Mini-haplotypes as lineage informative SNPs and ancestry inference SNPs European Journal of Human Genetics. ,vol. 20, pp. 1148- 1154 ,(2012) , 10.1038/EJHG.2012.69
Kenneth K Kidd, William C Speed, Criteria for selecting microhaplotypes: mixture detection and deconvolution. Investigative Genetics. ,vol. 6, pp. 1- 10 ,(2015) , 10.1186/S13323-014-0018-3
Tian Feng, Tingting Geng, Yongjun He, Manling Luo, Hua Yang, Longli Kang, Tianbo Jin, Dongya Yuan, Genetic polymorphisms of pharmacogenomic VIP variants in the lhoba population of southwest China. International Journal of Clinical and Experimental Pathology. ,vol. 8, pp. 13293- 13303 ,(2015)