[Traumatic childhood background, impulsiveness and hypothalamus-pituitary-adrenal axis dysfunction in eating disorders. A pilot study].

摘要: INTRODUCTION Some studies have stressed the importance of childhood traumatic events in etiology eating disorders (ED), suggesting that abnormalities response mechanisms to stress and functioning hypothalamus, pituitary-adrenal axis (HPA) could be important physiopathology behavior disorders. preliminary findings suggest some ED subtypes, as post-traumatic disorder, a hyperreactivity state HPA with increased sensitivity dexamethasone. METHODS A total 25 patients diagnosed according DSM-IV criteria, without any major depressive episode or history bipolar psychotic disorder were included. To assess axis, dexamethasone suppression test was performed 0.25 mg. The administered Bernstein trauma questionnaire, Green impulsiveness specific questionnaires SCID-II questionnaire for personality RESULTS 12% had background did not show relationship EBD subtype. most impulsive more borderline traits significantly greater number backgrounds (p<0.005). significant found between cortisol presence lower post-dexamethasone plasma levels CONCLUSIONS Trauma is associated entails an dysfunction translated into enhanced cortisol.