Reassessing the hemostatic disorder associated with acute promyelocytic leukemia.
作者： MS Tallman , HC Kwaan
DOI: 10.1182/BLOOD.V79.3.543.543
关键词:
摘要: of the prothrombin (PT), activated partial thromboplastin (PTT) and thrombin times (TT), increased levels fibrin degradation products (FDPs), hypofibrin~genemia.~~~"~~~~~ These findings are not diagnostic any single coagulation disorder, but reflect a complex interaction several pathophysiologic processes depicted in Fig 1. The first most generally recognized abnormality is release procoagulants from APL cells resulting DIC. Several types procoagulant activity have been found capable activating factor X through both intrinsic extrinsic pathways, including tissue factorlike
ashpublications.org
bloodjournal.org参考文章(71)
Michael E. Jones, Abdus Saleem, Acute promyelocytic leukemia The American Journal of Medicine. ,vol. 65, pp. 673- 677 ,(1978) , 10.1016/0002-9343(78)90856-2
EL Wilson, P Jacobs, EB Dowdle, The secretion of plasminogen activators by human myeloid leukemic cells in vitro Blood. ,vol. 61, pp. 568- 574 ,(1983) , 10.1182/BLOOD.V61.3.568.568
Henry K. Tan, Bettye Wages, Harvey R. Gralnick, Ultrastructural studies in acute promyelocytic leukemia. Blood. ,vol. 39, pp. 628- 636 ,(1972) , 10.1182/BLOOD.V39.5.628.628
MA Goldberg, D Ginsburg, RJ Mayer, RM Stone, M Maguire, DS Rosenthal, JH Antin, Is heparin administration necessary during induction chemotherapy for patients with acute promyelocytic leukemia Blood. ,vol. 69, pp. 187- 191 ,(1987) , 10.1182/BLOOD.V69.1.187.187
ED Sprengers, C Kluft, Plasminogen activator inhibitors. Blood. ,vol. 69, pp. 381- 387 ,(1987) , 10.1182/BLOOD.V69.2.381.BLOODJOURNAL692381
PW Wijermans, VI Rebel, GJ Ossenkoppele, PC Huijgens, MM Langenhuijsen, Combined procoagulant activity and proteolytic activity of acute promyelocytic leukemic cells: reversal of the bleeding disorder by cell differentiation. Blood. ,vol. 73, pp. 800- 805 ,(1989) , 10.1182/BLOOD.V73.3.800.800
RM Stone, M Maguire, MA Goldberg, JH Antin, DS Rosenthal, RJ Mayer, Complete remission in acute promyelocytic leukemia despite persistence of abnormal bone marrow promyelocytes during induction therapy: experience in 34 patients. Blood. ,vol. 71, pp. 690- 696 ,(1988) , 10.1182/BLOOD.V71.3.690.BLOODJOURNAL713690
Jean Bernard, Marise Weil, Michel Boiron, Claude Jacquillat, Georges Flandrin, Marie-François Gemon, Acute Promyelocytic Leukemia: Results of Treatment by Daunorubicin Blood. ,vol. 41, pp. 489- 496 ,(1973) , 10.1182/BLOOD.V41.4.489.489
KA Bauer, RD Rosenberg, Thrombin generation in acute promyelocytic leukemia. Blood. ,vol. 64, pp. 791- 796 ,(1984) , 10.1182/BLOOD.V64.4.791.791
F M Booyse, G Osikowicz, S Feder, J Scheinbuks, Isolation and characterization of a urokinase-type plasminogen activator (Mr = 54,000) from cultured human endothelial cells indistinguishable from urinary urokinase. Journal of Biological Chemistry. ,vol. 259, pp. 7198- 7205 ,(1984) , 10.1016/S0021-9258(17)39857-5