18F-FDG-PET/CT in Canine Mammary Gland Tumors.

摘要: Medical imaging techniques play a central role in clinical oncology, helping to obtain important information about the extent of disease, and plan treatment. Advanced modalities such as Positron Emission Tomography–Computed Tomography (PET/CT), may help whole-body staging single procedure, although lesions should be carefully interpreted. PET/CT is becoming commonly used canine cancer patients, but there still limited available on specific tumors mammary cancer. We evaluated utility fluorine-18 fluorodeoxyglucose (18F-FDG)-PET/CT detect malignant 8 female dogs with naturally occurring tumors. A scan was performed prior surgery, non-mammary detected either or during pre-surgical physical exam were resected when possible submitted for histopathological examination. Multiple involving different glands 5/8 dogs, total 23 lesions; 11 non-mammary-located 6/8 three these lung lymph node metastasis. 34 analyzed: 22 (19 3 metastatic lesions), 12 benign (4 tissues). Glucose uptake by maximum standardized value (SUVmax) analyzed correlated tumor size, versus pathology. found that minimum size needed distinguish according SUVmax 1.5cm; 2 100% sensitive malignancy. Combining data, >1.5cm >2 had positive predictive 100%. Finally, we did not find an association between histologic subtype grade, which present larger sample. Thus, 18F-FDG useful distinguishing from lesion further diverse tumors, establish characteristic SUV cutoffs detecting primary them lesions.