Incidence and predictors of seizures in patients with alzheimer's disease

摘要: Summary: Purpose: To determine cumulative incidence and predictors of new-onset seizures in mild Alzheimer’s disease (AD) with a cohort followed prospectively. Limited information is available on the seizures, no reports exist seizure AD patients. Methods: Mild patients were prospectively at 6-month intervals to estimate unprovoked compare age-specific risk population norms, identify characteristics baseline (demographics, duration severity AD, physical diagnostic test findings, comorbid medical psychiatric conditions) influencing risk. Review study charts records supplemented coded end-point data. Results: The 7 years was nearly 8%. In all age groups, increased compared standard population, an 87-fold increase youngest group (age 50‐59 years) more than threefold oldest 85+ years). multivariate modeling, independent younger [relative (RR), 0.89 per year age; 95% confidence interval (CI), 0.82‐0.97], African-American ethnic background (RR, 7.35; CI, 1.42‐37.98), more-severe dementia 4.15; 1.06‐16.27), focal epileptiform findings electroencephalogram (EEG) 73.36; 1.75‐3075.25). Conclusions: Seizure people starting mild-to-moderate AD. Younger individuals, African Americans, those or EEG likely have seizures. Key Words: disease—Seizures— Cumulative incidence—Predictors—Prospective cohort.