The development of xenograft glioblastoma implants in nude mice brain.
作者： Otilia Zarnescu , R Radulescu , F M Brehar , Mihaela Chivu , Denisa Dragu
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摘要: The inefficacity of the actual therapies for glioblastoma multiformis stimulates researchers to search new and innovative therapies. Therefore, development in vivo model is an essential step during these researches, being a link between cells cultures studies first phases clinical trials. In this paper, we present several procedures which have been performed time our country, such as: cultivation manipulation U87MG line, athymic – knock–out mice (NUDE Crl: CD–1 Foxn1), stereotactic inoculation finally xenograft brain inoculated nude mice. These results, offer from country glioblastoma, could be start point projects oriented raise performance scientific research European level.
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