HER2 as a potential biomarker of lymph node metastasis in undifferentiated early gastric cancer.

摘要: Human epidermal growth factor receptor 2 (HER2) is implicated in several cancers, including gastric cancer. However, limited data are available regarding its clinical significance early cancer (EGC). We evaluated the of HER2 overexpression patients with EGC. retrospectively reviewed 727 who underwent surgical treatment for EGC between October 2010 and August 2017. expression was analysed 680 cases by immunohistochemistry classified as negative (0 1+), equivocal (2+), or positive [overexpression (3+)]. Among differentiated EGC, number not significantly different from that HER2-negative terms age, sex, tumour size, location, gross type, depth invasion, presence lymphovascular invasion (LVI), lymph node metastasis (LNM). undifferentiated correlated LVI LNM compared patients. Multivariate analysis indicated a good predictive marker associated Therefore, importance should be overlooked, further studies needed to identify significance.