Inhibition of miR-126 protects chondrocytes from IL-1β induced inflammation via upregulation of Bcl-2.

作者: C. D. Yu , W. H. Miao , Y. Y. Zhang , M. J. Zou , X. F. Yan

DOI: 10.1302/2046-3758.76.BJR-2017-0138.R1

关键词:

摘要: Objectives The aim of this study was to investigate the role miR-126 in development osteoarthritis, as well potential molecular mechanisms involved, order provide a theoretic...

参考文章(28)
Huaming Xue, Yihui Tu, Tong Ma, Xiaodong Liu, Tao Wen, Minwei Cai, Zhidao Xia, Jiong Mei, Lactoferrin Inhibits IL-1β-Induced Chondrocyte Apoptosis Through AKT1-Induced CREB1 Activation. Cellular Physiology and Biochemistry. ,vol. 36, pp. 2456- 2465 ,(2015) , 10.1159/000430206
Gary Gibson, Hiroshi Asahara, microRNAs and cartilage. Journal of Orthopaedic Research. ,vol. 31, pp. 1333- 1344 ,(2013) , 10.1002/JOR.22397
Jagat R Kanwar, Rasika M Samarasinghe, Kuldeep Kumar, Ramesh Arya, Sanjeev Sharma, Shu-Feng Zhou, Sreenivasan Sasidharan, Rupinder K Kanwar, None, Cissus quadrangularis inhibits IL-1β induced inflammatory responses on chondrocytes and alleviates bone deterioration in osteotomized rats via p38 MAPK signaling. Drug Design Development and Therapy. ,vol. 9, pp. 2927- 2940 ,(2015) , 10.2147/DDDT.S77369
Faeza Ebrahimi, Vinod Gopalan, Riajul Wahab, Cu-Tai Lu, Robert Anthony Smith, Alfred King-Yin Lam, Deregulation of miR-126 expression in colorectal cancer pathogenesis and its clinical significance Experimental Cell Research. ,vol. 339, pp. 333- 341 ,(2015) , 10.1016/J.YEXCR.2015.10.004
Ting Yan, Yan Liu, Kai Cui, Bin Hu, Fang Wang, Li Zou, MicroRNA-126 regulates EPCs function: implications for a role of miR-126 in preeclampsia. Journal of Cellular Biochemistry. ,vol. 114, pp. 2148- 2159 ,(2013) , 10.1002/JCB.24563
Richard F. Loeser, Steven R. Goldring, Carla R. Scanzello, Mary B. Goldring, Osteoarthritis: A disease of the joint as an organ Arthritis & Rheumatism. ,vol. 64, pp. 1697- 1707 ,(2012) , 10.1002/ART.34453
Ying-Jung Chen, Wen-Hsin Liu, Pei-Hsiu Kao, Jeh-Jeng Wang, Long-Sen Chang, Involvement of p38 MAPK- and JNK-modulated expression of Bcl-2 and Bax in Naja nigricollis CMS-9-induced apoptosis of human leukemia K562 cells. Toxicon. ,vol. 55, pp. 1306- 1316 ,(2010) , 10.1016/J.TOXICON.2010.01.024
Xiaoying Wang, Peng Liu, Hua Zhu, Yanfeng Xu, Chunmei Ma, Xiaowei Dai, Lan Huang, Yali Liu, Lianfeng Zhang, Chuan Qin, miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation. Brain Research Bulletin. ,vol. 80, pp. 268- 273 ,(2009) , 10.1016/J.BRAINRESBULL.2009.08.006
Heba W.Z. Khella, Andreas Scorilas, Roy Mozes, Lorna Mirham, Evi Lianidou, Sergey N. Krylov, Jason Y. Lee, Michael Ordon, Robert Stewart, Michael A.S. Jewett, George M. Yousef, Low Expression of miR-126 Is a Prognostic Marker for Metastatic Clear Cell Renal Cell Carcinoma The American Journal of Pathology. ,vol. 185, pp. 693- 703 ,(2015) , 10.1016/J.AJPATH.2014.11.017
A. Cimmino, G. A. Calin, M. Fabbri, M. V. Iorio, M. Ferracin, M. Shimizu, S. E. Wojcik, R. I. Aqeilan, S. Zupo, M. Dono, L. Rassenti, H. Alder, S. Volinia, C.-g. Liu, T. J. Kipps, M. Negrini, C. M. Croce, miR-15 and miR-16 induce apoptosis by targeting BCL2. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 13944- 13949 ,(2005) , 10.1073/PNAS.0506654102