Pro- and Anticonvulsant Effects of the Ant Dinoponera quadriceps (Kempf) Venom in Mice.
作者： DAMF Nôga , FC Cagni , JR Santos , D Silva , DLO Azevedo
DOI: 10.1007/S13744-015-0292-7
关键词:
摘要: Epilepsy affects at least 50 million people worldwide, and the available treatment is associated with various side effects. Approximately 20–30% of patients develop seizures that persist despite careful monitored antiepileptic drugs. Thus, there a clear need for development new drugs, venoms can be an excellent source probes. In this context, while are studies on from snakes, scorpions, spiders, little known regarding venom ants. The aim study was to investigate potential pro- anticonvulsant effects ant Dinoponera quadriceps (Kempf) in Swiss mice. After injection crude (DqTx—5, 50, 500 mg/mL) lateral ventricle mice, we observed reduction exploration grooming behaviors, as well increase immobility duration. addition, induced procursive behavior tonic-clonic highest concentration. Conversely, preadministration denatured (AbDq) concentration 2 mg/mL protected animals against (66.7%) death (100%) by administration bicuculline. Taken together, findings demonstrate D. might anticonvulsants molecules.
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