Immunohistochemical studies on clustered pericapillary bodies in the spinal cord of post-poliomyelitis patients.

作者: Akito Ikemoto , A. Hirano

DOI: 10.1007/S004010050504

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摘要: This report concerns the study of clustered pericapillary bodies in spinal cords four post-poliomyelitis patients. All had stable neurological deficits without new symptoms after initial poliomyelitis infection. Spinal from seven individuals who died non-neurological disorders served as controls. Lumbar segments were examined by using conventional staining procedures and immunohistochemical techniques. The histological features structures similar to those previously described rosettes. number was strikingly greater one patient (a man at age 48) than other three. great majority within areas lesions. A small abnormal detected lumbar cord three control individuals. immunostained antibodies phosphorylated neurofilament, synaptophysin, ubiquitin, but not glial fibrillary acidic protein, tau paired helical filaments. These results indicate that may derive presynaptic terminals preterminal axons, their formation be related, albeit necessarily a specific fashion, disease process.

参考文章(20)
D. W. Dickson, S. H. Yen, A. Crowe, Monoclonal antibodies to Alzheimer neurofibrillary tangles. 1. Identification of polypeptides. American Journal of Pathology. ,vol. 120, pp. 282- 291 ,(1985)
L. Autilio-Gambetti, E. Cochran, L. M. Sayre, A. Patton, P. Gambetti, S. Hite, T. Mizutani, E. Izeki, B. Bacci, M. G. Nunzi, Amyloid beta precursor protein and ubiquitin epitopes in human and experimental dystrophic axons. Ultrastructural localization. American Journal of Pathology. ,vol. 144, pp. 702- 710 ,(1994)
L. Autilio-Gambetti, E. Cochran, A. Patton, P. Gambetti, B. Bacci, Y. Chen, Amyloid precursor protein and ubiquitin immunoreactivity in dystrophic axons is not unique to Alzheimer's disease. American Journal of Pathology. ,vol. 139, pp. 485- 489 ,(1991)
P. Averback, A new type of inclusion body in human spinal cord Acta Neuropathologica. ,vol. 71, pp. 106- 110 ,(1986) , 10.1007/BF00687970
David Bodian, Histopathologic basis of clinical findings in poliomyelitis The American Journal of Medicine. ,vol. 6, pp. 563- 578 ,(1949) , 10.1016/0002-9343(49)90130-8
L I Binder, A Frankfurter, L I Rebhun, The distribution of tau in the mammalian central nervous system. Journal of Cell Biology. ,vol. 101, pp. 1371- 1378 ,(1985) , 10.1083/JCB.101.4.1371
Sozos Ch. Papasozomenos, Lester I. Binder, Phosphorylation determines two distinct species of Tau in the central nervous system. Cytoskeleton. ,vol. 8, pp. 210- 226 ,(1987) , 10.1002/CM.970080303
AKITO IKEMOTO, ASAO HIRANO, Immunohistochemical study on synaptophysin in the spinal cord of chronic anterior poliomyelitis. Annals of the New York Academy of Sciences. ,vol. 753, pp. 381- 385 ,(1995) , 10.1111/J.1749-6632.1995.TB27567.X