What is the evidence for Sjögren's syndrome being triggered by viral infection? Subplot: infections that cause clinical features of Sjögren's syndrome.

摘要: Purpose of review To clarify the involvement viral infections in pathogenesis Sjogren's syndrome and to discuss whether viruses can be a trigger for development syndrome. Recent findings Although some are candidate triggers syndrome, we focus on human T lymphotropic virus type I (HTLV-I). Clinicoepidemiological studies show relationship between HTLV-I with low frequency salivary gland damage magnetic resonance imaging, autoantibody production ectopic germinal center HTLV-I-associated myelopathy (HAM) patients Our recent study showed that has potential infect epithelial cells (SGECs). After coculture HCT-5 (an HTLV-I-infected T-cell line derived from cerebrospinal fluid) an HAM patient SGECs, observed time-dependent increases levels soluble intracellular adhesion molecule1, interferon gamma-induced protein 10 kDa regulated activation, normal expressed secreted. In addition, SGECs themselves express these molecules along expression proteins. Summary is involved HTLV-I-seropositive By infecting CD4 vivo, induces specific clinicopathological conditions. have augment cell adhesion, inflammation migration.